The personal advertisement coincided with the newspaper story of Zodiac on August 26th 1976, so it would appear that the personal advertisement could not be a response to the San Francisco Chronicle article, unless the Zodiac Killer (or author) knew in advance that the story of David Toschi and his drive to solve the case in absence of his long time partner, was about to break in the newspapers. This, of course, would require the author of the advertisement to have prior knowledge to its publication, such as somebody connected to law enforcement or the San Francisco Chronicle newspaper
Contact with David Toschi would become a feature of future Zodiac letters, such as on April 24th 1978 and October 28th 1987, as well as inferences (through the wording used) in the May 6th 1986 letter, and questionable July 19th 1978 Scotch Tape communication. Therefore, based on the correlation between the language used in the personal advertisement and newspaper article featuring David Toschi on August 26th 1976, the threat to "terminate his case" could be perceived as a direct threat on the life of the renowned Zodiac investigator. The newspaper article closed with: "I don't know if I'll ever get the case solved, but I'm sure as hell trying, Toschi said gamely".